Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation
نویسندگان
چکیده
منابع مشابه
Hepatitis C virus targets DC-SIGN and L-SIGN to escape lysosomal degradation.
Hepatitis C virus (HCV) is a major health problem. However, the mechanism of hepatocyte infection is largely unknown. We demonstrate that the dendritic cell (DC)-specific C-type lectin DC-SIGN and its liver-expressed homologue L-SIGN/DC-SIGNR are important receptors for HCV envelope glycoproteins E1 and E2. Mutagenesis analyses demonstrated that both HCV E1 and E2 bind the same binding site on ...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 2004
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.78.15.8322-8332.2004